2-氮杂双环[2.2.1]庚烷-3-酮合成路线 （共 4 条）
反应条件
1: 93 percent / aq. HCl / 48 h / 20 °C 2: DIEA / H2O; dioxane / 3 h / 20 °C View Scheme
参考文献
Rodriguez-Vazquez, Nuria; Salzinger, Stephan; Silva, Luis F.; Amorin, Manuel; Granja, Juan R.
European Journal of Organic Chemistry, 2013 , # 17 p. 3477 - 3493
反应条件
lithium aluminium tetrahydride in diethyl ether 1) 20 deg C, 1 h, 2) reflux, 6 h;
参考文献
Heesing, Albert; Herdering, Wilhelm
Chemische Berichte, 1983 , vol. 116, # 3 p. 1081 - 1096
反应条件
1: 93 percent / aq. HCl / 48 h / 20 °C 2: DIEA / H2O; dioxane / 3 h / 20 °C View Scheme
参考文献
Brea, Roberto J.; Amorin, Manuel; Castedo, Luis; Granja, Juan R.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 35 p. 5710 - 5713
反应条件
hydrogenchloride in methanol
T=20°C; 72 h;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2004/94371 A2, 2004 ;
Location in patent: Page 86 ;
WO 2004/094371 A2
