甲基4-硝基-2-噻吩羧酸酯合成路线 （共 13 条）
反应条件
1: thiophene-2-carboxylic acid With sulfuric acid; nitric acid T=0 - 10°C; 1.25 h; 2: methanol With thionyl chloride T=20°C; Reflux;
参考文献
WO2010/29577 A2, ;
Page/Page column 38-39 ;
反应条件
1: tetrabutylammonium permanganate / pyridine View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1331 - 1335
反应条件
methanol; sulfuric acid
参考文献
Journal of the American Chemical Society, , vol. 77, p. 577
反应条件
1: nitric acid; sulfuric acid / -5 °C 2: sodium dichromate; aqueous sulfuric acid 3: sulfuric acid; methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 577
反应条件
sulfuric acid; nitric acid -20 deg C, then allowed to warm to 0 deg C over 0.5 h; Yields of byproduct given;
参考文献
Elliot, Richard, L.; O'Hanlon, Peter J.; Rogers, Norman H.
Tetrahedron, 1987 , vol. 43, # 14 p. 3295 - 3302
反应条件
nitric acid; acetic anhydride T=-10°C; 0.5 h; Yields of byproduct given;
参考文献
Cogolli, Pietro; Maiolo, Filippo; Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 1331 - 1335
反应条件
1: hydrogen chloride 2: acetic acid anhydride; acetic acid; nitric acid View Scheme
参考文献
Annales Pharmaceutiques Francaises, , vol. 11, p. 509,518
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1331 - 1335
反应条件
hydrogenchloride; zinc in methanol Ambient temperature;
参考文献
Arcamone, Federico Maria; Animati, Fabio; Barbieri, Brunella; Configliacchi, Emanuela; D'Alessio, Roberto; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 774 - 778
反应条件
sulfuric acid in water 1.5 h; Heating;
参考文献
Elliot, Richard, L.; O'Hanlon, Peter J.; Rogers, Norman H.
Tetrahedron, 1987 , vol. 43, # 14 p. 3295 - 3302
