2-氨基-4-甲氧基-5-(3-吗啉丙氧基)苯甲酰胺合成路线 （共 10 条）
反应条件
potassium hydroxide in 1,1-dimethylpropan-1-ol T=82°C;
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
hydrogen; nickel in methanol T=25 - 30°C; P=1034.32 - 1292.9 Torr; 2 h; Product distribution / selectivity;
参考文献
NATCO PHARMA LIMITED; JYOTHI PRASAD, Ramanadham; PULLA REDDY, Muddasani; NAGESHWARA RAO, Bollepalli; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2005/70909 A1, 2005 ;
Location in patent: Page/Page column 29 ;
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 2: 75 percent / sodium dithionite / H2O / 20 - 50 °C 3: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1: 75 percent / sodium dithionite / H2O / 20 - 50 °C 2: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1: 88 percent / sodium formate; formic acid; hydroxylamine sulfate / 8 h / 85 °C 2: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 3: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 4: 75 percent / sodium dithionite / H2O / 20 - 50 °C 5: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 10 h / 85 °C 2: 95 percent / aq. H2SO4; HNO3; AcOH / 50 h / 20 °C 3: 75 percent / sodium dithionite / H2O / 20 - 50 °C 4: 38 percent / KOH / 2-methyl-butan-2-ol / 82 °C View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1.1: formamide / 20 - 100 °C 1.2: 78 percent / 7 h / 100 °C 2.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C 3.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating 4.1: 54 percent / LiCl / dimethylformamide / 15 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
反应条件
1.1: formamide / 20 - 100 °C 1.2: 78 percent / 7 h / 100 °C 2.1: 90 percent / POCl3; triethylamine / toluene / 24 h / 58 °C 3.1: 91 percent / triethylamine / propan-2-ol / 288 h / Heating View Scheme
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
反应条件
1: With formamide T=20 - 100°C; 2: T=100°C; 7 h;
参考文献
Wang, Ji-Quan; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 15 p. 4102 - 4106
