(2E)-3-(3-氯苯基)丙烯酰胺合成路线 （共 6 条）
反应条件
ammonia in dichloromethane; chloroform T=-78 - 20°C;
参考文献
Pfizer Inc.
Patent: US2005/203086 A1, 2005 ;
Location in patent: Page/Page column 46 ;
US 20050203086 A1
反应条件
ammonia in thionyl chloride; dichloromethane; chloroform
参考文献
Pfizer Inc.
Patent: US6288120 B1, 2001 ;
反应条件
in 1,2-dichloro-ethane 3 h; Reflux;
参考文献
King, Frank D.; Caddick, Stephen
Tetrahedron, 2013 , vol. 69, # 2 p. 487 - 491
反应条件
1: dichloromethane; N,N-dimethyl-formamide; chloroform / 2 h / 20 °C 2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 3: 1,2-dichloro-ethane / 3 h / |Reflux View Scheme
参考文献
King, Frank D.; Caddick, Stephen
Tetrahedron, 2013 , vol. 69, # 2 p. 487 - 491
反应条件
1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 2: 1,2-dichloro-ethane / 3 h / |Reflux View Scheme
参考文献
King, Frank D.; Caddick, Stephen
Tetrahedron, 2013 , vol. 69, # 2 p. 487 - 491
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 47 h; 2: With water in tetrahydrofuran
参考文献
Pfizer Inc.
Patent: US6288120 B1, 2001 ;
