3-甲基苯并呋喃-2-羧酸合成路线 （共 24 条）
反应条件
1: tetrachloromethane; N-bromo-succinimide / auch unter Zusatz von Dibenzoylperoxid 2: quinoline 3: aqueous methanol. NaOH-solution View Scheme
参考文献
Helvetica Chimica Acta, , vol. 31, p. 78,80
反应条件
1: quinoline 2: aqueous methanol. NaOH-solution View Scheme
参考文献
Helvetica Chimica Acta, , vol. 31, p. 78,80
参考文献
Chemische Berichte, , vol. 41, p. 831
反应条件
acetyl chloride 17 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/10008 A1, 2006 ;
Location in patent: Page/Page column 167 ;
WO 2006/010008 A1
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene 2 h; Ambient temperature;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
in diethyl ether 0.333333 h; Ambient temperature;
参考文献
Suzuki; Horaguchi; Shimizu; Abe
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2762 - 2767
反应条件
in methanol; chloroform
参考文献
Dorsey; McDonough; McDaniel; Levin; Newton; Hoffman; Darke; Zugay-Murphy; Emini; Schleif; Olsen; Stahlhut; Rutkowski; Kuo; Lin; Chen; Michelson; Holloway; Huff; Vacca
Journal of Medicinal Chemistry, 2000 , vol. 43, # 18 p. 3386 - 3399
反应条件
thionyl chloride; benzene
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2006/10008 A1, 2006 ;
Location in patent: Page/Page column 172-173 ;
WO 2006/010008 A1
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
AFFINIUM PHARMACEUTICALS, INC.; PARTRIDGE, John, J.; COLUCCI, John; GAREAU, Yves; THERIEN, Michel; ZAMBONI, Robert; HAFKIN, Barry; MARFAT, Anthony; ZAGHDANE, Helmi
Patent: WO2013/190384 A1, 2013 ;
Location in patent: Paragraph 00202 ;
反应条件
acetic acid; silver carbonate in dimethyl sulfoxide T=120°C; 16 h;
参考文献
Lu, Pengfel; Sanchez, Carolina; Cornella, Josep; Larrosa, Igor
Organic Letters, 2009 , vol. 11, # 24 p. 5710 - 5713
