3-甲基苯并呋喃-2-羧酸合成路线 （共 24 条）
反应条件
palladium (II) trifluoroacetate; silver carbonate in dimethyl sulfoxide; N,N-dimethyl-formamide T=115°C; 16 h; Inert atmosphere;
参考文献
Cornella, Josep; Lahlali, Hicham; Larrosa, Igor
Chemical Communications, 2010 , vol. 46, # 43 p. 8276 - 8278
反应条件
1: 100 percent / DBU / benzene / 2 h / Ambient temperature 2: 87 percent / DIBAL / hexane; tetrahydrofuran / 1 h / Ambient temperature 3: 65 percent / MnO2 / benzene / Ambient temperature View Scheme
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
nitric acid; tin(IV) chloride in dichloromethane
T=0°C; 2 h;
参考文献
Einhorn, Jacques; Demerseman, Pierre; Royer, Rene
Canadian Journal of Chemistry, 1983 , vol. 61, p. 2287 - 2290
反应条件
1: dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C
2: dichloromethane / 2 h / 0 - 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / |Heating; |Reflux
View Scheme
参考文献
AFFINIUM PHARMACEUTICALS, INC.; PARTRIDGE, John, J.; COLUCCI, John; GAREAU, Yves; THERIEN, Michel; ZAMBONI, Robert; HAFKIN, Barry; MARFAT, Anthony; ZAGHDANE, Helmi
Patent: WO2013/190384 A1, 2013 ;
