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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4-氨基苯酚甲磺酸酯
合成路线
（共 9 条）
20455-07-6
对硝基苯基甲烷磺酸酯
→
反应条件
24690-19-5
4-氨基苯酚甲磺酸酯
反应条件
hydrogen; Ra-Ni in ethanol; ethyl acetate T=23°C; P=72400.7 Torr; 24 h;
参考文献
Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi
Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
100-02-7
对硝基苯酚
→
反应条件
24690-19-5
4-氨基苯酚甲磺酸酯
反应条件
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: iron; ammonium chloride / ethanol; water / 20 °C / |Reflux View Scheme
参考文献
Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi
Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
466639-53-2
2-溴-1-碘-4-甲氧基苯
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 2.1: sulfuric acid / water; acetonitrile / 0.17 h / 0 °C 2.2: 1.5 h / 0 - 5 °C 2.3: 0.25 h / 0 °C 3.1: potassium hydroxide / methanol; dichloromethane / 1 h / 20 °C / |Inert atmosphere 4.1: potassium carbonate / acetone / 16 h / |Reflux View Scheme
参考文献
Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi
Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
191719-02-5
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h;
参考文献
Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi
Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
22149-28-6
11-羟基他波宁
反应条件
1.1: 0.33 h / 70 °C 2.1: HNO3 / 0.5 h / 0 °C 3.1: HCl / methanol / 2 h / 70 °C 4.1: NaNO2; aq. HCl / ethyl acetate / -15 °C 4.2: KI / ethyl acetate / 0.25 h / -15 °C 5.1: 83 percent / BnEt3NCl / Pd(OAc)2 / dimethylformamide / 2 h / 50 °C 6.1: NaBH4 / methanol / 0.5 h / -15 °C 7.1: pyridine / 0.25 h / 20 °C 8.1: Zn; AcOH / CH2Cl2 / 0.5 h / 20 °C 9.1: Ac2O / CH2Cl2 / 0.5 h / 0 °C 10.1: 89 percent / POCl3; pyridine / CH2Cl2 / 0.67 h / 0 °C 11.1: n-Bu3SnH; AIBN / acetonitrile / 0.5 h / 80 °C 11.2: I2 / acetonitrile / 0.33 h / 20 °C 12.1: Et3N; DMAP / acetonitrile / 1 h / 20 °C 13.1: Ph3As; CuI / BnPd(PPh3)2Cl / hexamethylphosphoric acid triamide; dimethylformamide / 3.5 h / 85 °C 14.1: Na2CO3; H2O / methanol / 2 h / 20 °C 15.1: 89 percent / diethyl azodicarboxylate; PPh3 / benzene; toluene / 0.5 h / 20 °C 16.1: TFA / CH2Cl2 / 0.25 h / 20 °C 17.1: pyrrolidine / methanol; acetonitrile / 0.08 h / 20 °C 18.1: pyrrolidine / methanol; acetonitrile / 4 h / Heating 19.1: 88 percent / PPh3 / CCl4; acetonitrile / 0.5 h / 70 °C 20.1: KOH / methanol / 0.75 h / 80 °C View Scheme
参考文献
Kobayashi, Satoshi; Ueda, Toshihiro; Fukuyama, Tohru
Synlett, 2000 , # 6 p. 883 - 886
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 0.33 h / 70 °C 2.1: HNO3 / 0.5 h / 0 °C 3.1: HCl / methanol / 2 h / 70 °C 4.1: NaNO2; aq. HCl / ethyl acetate / -15 °C 4.2: KI / ethyl acetate / 0.25 h / -15 °C 5.1: 83 percent / BnEt3NCl / Pd(OAc)2 / dimethylformamide / 2 h / 50 °C 6.1: NaBH4 / methanol / 0.5 h / -15 °C 7.1: pyridine / 0.25 h / 20 °C 8.1: Zn; AcOH / CH2Cl2 / 0.5 h / 20 °C 9.1: Ac2O / CH2Cl2 / 0.5 h / 0 °C 10.1: 89 percent / POCl3; pyridine / CH2Cl2 / 0.67 h / 0 °C 11.1: n-Bu3SnH; AIBN / acetonitrile / 0.5 h / 80 °C 11.2: I2 / acetonitrile / 0.33 h / 20 °C 12.1: Et3N; DMAP / acetonitrile / 1 h / 20 °C 13.1: Ph3As; CuI / BnPd(PPh3)2Cl / hexamethylphosphoric acid triamide; dimethylformamide / 3.5 h / 85 °C 14.1: Na2CO3; H2O / methanol / 2 h / 20 °C 15.1: 89 percent / diethyl azodicarboxylate; PPh3 / benzene; toluene / 0.5 h / 20 °C 16.1: TFA / CH2Cl2 / 0.25 h / 20 °C 17.1: pyrrolidine / methanol; acetonitrile / 0.08 h / 20 °C 18.1: pyrrolidine / methanol; acetonitrile / 4 h / Heating 19.1: 88 percent / PPh3 / CCl4; acetonitrile / 0.5 h / 70 °C 20.1: KOH / methanol / 0.75 h / 80 °C 21.1: t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 1.5 h / 0 °C 22.1: 88 percent / (PhSeO)2O / benzene / 0.5 h / 80 °C 23.1: MCPBA; NaHCO3; H2O / methanol; CH2Cl2 / 0.08 h / 0 °C 24.1: NaBH3CN; aq. HCl / methanol; CH2Cl2 / 0.58 h / 0 - 20 °C / pH 3.0 24.2: NaHSO3; Na2CO3 / aq. methanol; CH2Cl2 / 0.5 h / 20 °C / pH 9 - 10 25.1: 91 percent / AcONa / 4 h / 20 °C View Scheme
参考文献
Kobayashi, Satoshi; Ueda, Toshihiro; Fukuyama, Tohru
Synlett, 2000 , # 6 p. 883 - 886
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
1037298-05-7
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 2.1: sulfuric acid / water; acetonitrile / 0.17 h / 0 °C 2.2: 1.5 h / 0 - 5 °C 2.3: 0.25 h / 0 °C 3.1: potassium hydroxide / methanol; dichloromethane / 1 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Noji, Toshiharu; Fujiwara, Hideto; Okano, Kentaro; Tokuyama, Hidetoshi
Organic Letters, 2013 , vol. 15, # 8 p. 1946 - 1949
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
3633-92-9
脱乙酰基文多灵
反应条件
1.1: 0.33 h / 70 °C 2.1: HNO3 / 0.5 h / 0 °C 3.1: HCl / methanol / 2 h / 70 °C 4.1: NaNO2; aq. HCl / ethyl acetate / -15 °C 4.2: KI / ethyl acetate / 0.25 h / -15 °C 5.1: 83 percent / BnEt3NCl / Pd(OAc)2 / dimethylformamide / 2 h / 50 °C 6.1: NaBH4 / methanol / 0.5 h / -15 °C 7.1: pyridine / 0.25 h / 20 °C 8.1: Zn; AcOH / CH2Cl2 / 0.5 h / 20 °C 9.1: Ac2O / CH2Cl2 / 0.5 h / 0 °C 10.1: 89 percent / POCl3; pyridine / CH2Cl2 / 0.67 h / 0 °C 11.1: n-Bu3SnH; AIBN / acetonitrile / 0.5 h / 80 °C 11.2: I2 / acetonitrile / 0.33 h / 20 °C 12.1: Et3N; DMAP / acetonitrile / 1 h / 20 °C 13.1: Ph3As; CuI / BnPd(PPh3)2Cl / hexamethylphosphoric acid triamide; dimethylformamide / 3.5 h / 85 °C 14.1: Na2CO3; H2O / methanol / 2 h / 20 °C 15.1: 89 percent / diethyl azodicarboxylate; PPh3 / benzene; toluene / 0.5 h / 20 °C 16.1: TFA / CH2Cl2 / 0.25 h / 20 °C 17.1: pyrrolidine / methanol; acetonitrile / 0.08 h / 20 °C 18.1: pyrrolidine / methanol; acetonitrile / 4 h / Heating 19.1: 88 percent / PPh3 / CCl4; acetonitrile / 0.5 h / 70 °C 20.1: KOH / methanol / 0.75 h / 80 °C 21.1: t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol / 1.5 h / 0 °C 22.1: 88 percent / (PhSeO)2O / benzene / 0.5 h / 80 °C 23.1: MCPBA; NaHCO3; H2O / methanol; CH2Cl2 / 0.08 h / 0 °C 24.1: NaBH3CN; aq. HCl / methanol; CH2Cl2 / 0.58 h / 0 - 20 °C / pH 3.0 24.2: NaHSO3; Na2CO3 / aq. methanol; CH2Cl2 / 0.5 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Kobayashi, Satoshi; Ueda, Toshihiro; Fukuyama, Tohru
Synlett, 2000 , # 6 p. 883 - 886
24690-19-5
4-氨基苯酚甲磺酸酯
→
反应条件
556038-75-6
反应条件
1.1: 94.5 g / Br2 / methanol; CH2Cl2 / 0.5 h / 0 - 23 °C 2.1: aq. NaNO2; H2SO4 / acetonitrile / 0 °C 2.2: 96 percent / aq. KI / acetonitrile / 0.75 h 3.1: 100 percent / KOH / CH2Cl2; methanol / 0.08 h / 23 °C View Scheme
参考文献
Yamada, Ken; Kurokawa, Toshiki; Tokuyama, Hidetoshi; Fukuyama, Tohru
Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6630 - 6631
