3,4-二氯-5-甲基吡咯-2-羧酸合成路线 （共 2 条）
反应条件
1: With methanol; lithium hydroxide; water in dichloromethane T=70°C; 2 h; 2: With hydrogenchloride; water in methanol; dichloromethane T=0°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/92608 A1, 2006 ;
Location in patent: Page/Page column 53-54 ;
WO 2006/092608 A1
反应条件
1: sulfuryl dichloride / tetrachloromethane 2: water; sodium hydroxide / methanol View Scheme
参考文献
Sherer, Brian A.; Hull, Kenneth; Green, Oluyinka; Basarab, Gregory; Hauck, Sheila; Hill, Pamela; Loch III, James T.; Mullen, George; Bist, Shanta; Bryant, Joanna; Boriack-Sjodin, Ann; Read, Jon; Degrace, Nancy; Uria-Nickelsen, Maria; Illingworth, Ruth N.; Eakin, Ann E.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7416 - 7420
