苯并二氢吡喃-2-甲酸乙酯合成路线 （共 8 条）
反应条件
palladium in methanol; diethyl ether; chloroform; acetic acid
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
sulfuric acid in dichloromethane 21 h; Heating;
参考文献
Urban; Moore
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 431 - 438
反应条件
in ethanol; dichloromethane
参考文献
Pfizer Inc.
Patent: US5089637 A1, 1992 ;
反应条件
1: 1.) CH3ONa, 2.) H2, AcOH / 2.) Pd/C 2: 93 percent / H2SO4 / CH2Cl2 / 21 h / Heating View Scheme
参考文献
Urban; Moore
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 431 - 438
参考文献
Palucki, Michael; Yasuda, Nobuyoshi
Tetrahedron Letters, 2005 , vol. 46, # 6 p. 987 - 990
反应条件
sodium borohydride in tetrahydrofuran; water; acetone
参考文献
Laboratorios Menarini S.A.
Patent: US5990142 A1, 1999 ;
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 - -30 °C / |Inert atmosphere
1.2: 3 h / -78 - 20 °C / |Inert atmosphere
2.1: dihydrogen peroxide / tetrahydrofuran; hexane / 3 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
Song, Song; Zhu, Shou-Fei; Pu, Liu-Yang; Zhou, Qi-Lin
Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6072 - 6075
Angew. Chem., 2013 , vol. 125, # 23 p. 6188 - 6191
反应条件
1: lipase from Pseudomonas fluorescens; sodium hydroxide / tetrahydrofuran; water / 20 °C / pH 8 / aq. phosphate buffer; Enzymatic reaction
2: ammonia; ammonium chloride / water / 2 h / 100 °C
3: diborane / tetrahydrofuran / Inert atmosphere; Reflux
View Scheme
参考文献
Marco, Isabel; Valhondo, Margarita; Martin-Fontecha, Mar; Vazquez-Villa, Henar; Del Rio, Joaquin; Planas, Anna; Sagredo, Onintza; Ramos, Jose A.; Torrecillas, Ivan R.; Pardo, Leonardo; Frechilla, Diana; Benhamu, Bellinda; Lopez-Rodriguez, Maria L.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 23 p. 7986 - 7999
