(8CI,9CI)-噻唑并[3,2-a]苯并咪唑合成路线 (共 10 条)
反应条件
copper(l) iodide; tetrabutyl ammonium fluoride; N-methyl-2-(methylamino)ethylamine in water; N,N-dimethyl-formamide
T=65°C; 12 h;
参考文献
Xu, Hui; Gu, Shaojin; Chen, Wanzhi; Li, Dacheng; Dou, Jianmin
Journal of Organic Chemistry, 2011 , vol. 76, # 8 p. 2448 - 2458
参考文献
Ogura,H. et al.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, # 11 p. 2167 - 2171
反应条件
1: H2O
2: H2SO4
View Scheme
参考文献
Krasovskii,A.N.; Kochergin,P.M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967 , vol. 3, p. 709 - 712
Khimiya Geterotsiklicheskikh Soedinenii, 1967 , vol. 3, p. 899 - 903
反应条件
1: aq. KOH / dioxane / 0.17 h / Ambient temperature
2: 0.17 h / 220 °C
View Scheme
参考文献
Davidson,A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1239 - 1245
反应条件
1: dimethylformamide / 24 h
2: aq. KOH / dioxane / 0.17 h / Ambient temperature
3: 0.17 h / 220 °C
View Scheme
参考文献
Davidson,A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1239 - 1245
反应条件
1: benzene / 30 h / Heating
2: aq. KOH / dioxane / 0.17 h / Ambient temperature
3: 0.17 h / 220 °C
View Scheme
参考文献
Davidson,A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1239 - 1245
反应条件
1: butan-2-one; H2O / 4 h / Heating
2: POCl3 / pyridine
View Scheme
参考文献
Alper,A.E.; Taurins,A.
Canadian Journal of Chemistry, 1967 , vol. 45, p. 2903 - 2912
反应条件
T=220°C; 0.166667 h;
参考文献
Davidson,A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 1239 - 1245
反应条件
1: POCl3
2: aq. H2SO4
View Scheme
参考文献
Krasovskii,A.N.; Kochergin,P.M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1967 , vol. 3, p. 709 - 712
Khimiya Geterotsiklicheskikh Soedinenii, 1967 , vol. 3, p. 899 - 903
参考文献
Hubert,A.J.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 1334 - 1336