7-氨基-3-甲氧基甲基-3-头孢烯-4-甲酸合成路线 （共 4 条）
反应条件
1: With boron trifluoride in sulfolane 2: With triethylamine in sulfolane; methanol; water
参考文献
WO2011/77217 A1, ;
Page/Page column 8 ;
反应条件
methanesulfonic acid; trifluorormethanesulfonic acid in methanol T=13 - 14°C; 0.75 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Liebigs Annales, , # 11 p. 1735 - 1741
反应条件
methanesulfonic acid; trifluorormethanesulfonic acid T=13 - 14°C; 0.75 h; Yield given. Yields of byproduct given;
参考文献
Liebigs Annales, , # 11 p. 1735 - 1741
反应条件
1: With triethylamine in methanol T=8 - 12°C; 2: With sulfuric acid in methanol; water T=0 - 20°C; pH=2.4 - 2.5; Product distribution / selectivity;
参考文献
NECTAR LIFESCIENCES LTD.; SAHOO, Prabhat, Kumar; SUNDARAVADIVELAN, Sivakumaran; MEHAR, Satish, Kumar; SHRIVASTAVA, Ajay, Kumar; SURULICHAMY, Senthil, Kumar
Patent: WO2011/77217 A1, 2011 ;
Location in patent: Page/Page column 9 ;
