1-苯基-4-哌啶羧酸乙酯合成路线 （共 4 条）
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=85°C; 1.5 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/46107 A1, 2004 ;
Location in patent: Page 226-227 ;
WO 2004/046107 A1
反应条件
Cu(II) pivalate in dichloromethane T=20°C; Etherification; 16 h;
参考文献
Sheppard, George S.
Synlett, 1999 , # 8 p. 1207 - 1210
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 2 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/46107 A1, 2004 ;
Location in patent: Page 227 ;
WO 2004/046107 A1
反应条件
sodium hydroxide in methanol
参考文献
Calvo, Raul R.; Cheung, Wing S.; Player, Mark R.
Patent: US2006/116368 A1, 2006 ;
Location in patent: Page/Page column 56; 57 ;
