N-[(2S)-4-甲基-1-[(2R)-2-甲基环氧乙烷-2-基]-1-氧代-2-戊基]氨基甲酸叔丁酯合成路线 (共 5 条)
反应条件
dihydrogen peroxide; benzonitrile; N-ethyl-N,N-diisopropylamine T=0 - 4°C; 43 h; Alkaline aqueous solution;
参考文献
Wang, Bin; Miao, Chengxia; Wang, Shoufeng; Xia, Chungu; Sun, Wei
Chemistry - A European Journal, 2012 , vol. 18, # 22 p. 6750 - 6753
反应条件
triethylamine in dichloromethane T=0 - 20°C; 13 h;
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.; NISHINO, Yukihiro; WAKUI, Kazuya; MURASE, Shota; SAKAI, Yoshifumi
Patent: WO2014/3203 A2, 2014 ;
Location in patent: Page/Page column 22-27 ;
反应条件
potassium peroxymonosulfate; 1,1,1-trifluoropropanone; sodium hydrogencarbonate in water; acetonitrile Inert atmosphere; diastereoselective reaction;
参考文献
CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew
Patent: WO2013/9923 A1, 2013 ;
Location in patent: Sheet 4; 5 ;
反应条件
1: 92 percent / diethyl ether / 2.5 h / -78 °C 2: H2O2, i-PrEtN / benzonitrile; H2O; methanol / 43 h / 0 - 4 °C View Scheme
参考文献
CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew
Patent: WO2013/9923 A1, 2013 ;
反应条件
1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h / 25 °C / Inert atmosphere 2: tetrahydrofuran / 6 h / 0 °C / Inert atmosphere 3: potassium peroxymonosulfate; 1,1,1-trifluoropropanone; sodium hydrogencarbonate / water; acetonitrile / Inert atmosphere View Scheme
参考文献
CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James
Patent: WO2014/18807 A1, 2014 ;