(R)-(-)-4-甲基苯亚磺酰胺合成路线 （共 17 条）
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 0 °C 1.2: 73 percent / tetrahydrofuran / 3 h / 20 °C 2.1: 35 percent / α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; aq. BES buffer; KCl / dimethylformamide / 96 h / pH 7.2 View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 10-11 p. 1183 - 1192
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-78 - 5°C; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 5 p. 1374 - 1375
反应条件
lithium hexamethyldisilazane in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Zhang, Yongda; Chitale, Sampada; Goyal, Navneet; Li, Guisheng; Han, Zhengxu S.; Shen, Sherry; Ma, Shengli; Grinberg, Nelu; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H.
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 690 - 695
反应条件
recombinant subtilisin E in water T=37°C; pH=8.0; 24 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
recombinant subtilisin E in water T=37°C; pH=8.0; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
recombinant subtilisin E in water T=37°C; pH=8.0; 24 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 7 p. 2104 - 2113
反应条件
1: quinidine acetate / CH2Cl2 / 1 h / -78 °C 2: LiHMDS / tetrahydrofuran / -78 - 5 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 5 p. 1374 - 1375
反应条件
α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; BES buffer; potassium chloride in N,N-dimethyl-formamide pH=7.2; 96 h;
参考文献
Savile, Christopher K.; Kazlauskas, Romas J.
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 10-11 p. 1183 - 1192
反应条件
1.1: oxalyl chloride / toluene / 1 h / 20 °C 1.2: 86 percent / NH4OH / toluene; ethyl acetate / 1 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C 2.2: 73 percent / tetrahydrofuran / 3 h / 20 °C 3.1: 35 percent / α-chymotrypsin (EC 3.4.21.21) from bovine pancreas; aq. BES buffer; KCl / dimethylformamide / 96 h / pH 7.2 View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 10-11 p. 1183 - 1192
反应条件
ammonia; lithium; iron nitrate (III) in tetrahydrofuran T=-78°C; 0.75 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 77, # 1 p. 690 - 695
