1,3-二氢-2-苯并噻吩 2,2-二氧化物合成路线 （共 27 条）
反应条件
tris (triphenylphosphine)rhodium(I) chloride in ethanol
T=25°C; 1 h;
参考文献
Grigg, Ronald; Scott, Ronald; Stevenson, Paul
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1357 - 1364
参考文献
Imperial Chemical Industries; ICI Pharma
Patent: US5208259 A1, 1993 ;
US 5208259 A
反应条件
hydroxymethanesulfinic acid sodium salt; potassium hydrogencarbonate in water; N,N-dimethyl-formamide
T=50°C; 28 h;
参考文献
Jarvis, William F.; Hoey, Michael D.; Finocchio, Alfred L.; Dittmer, Donald C.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5750 - 5756
反应条件
palladium on activated charcoal in benzene
15 h; Heating;
参考文献
Aitken, R. Alan; Cadogen, J. I. G.; Gosney, Ian; Newlands, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 16 p. 2301 - 2308
反应条件
1: 75 percent / m-chloroperbenzoic acid / diethyl ether / 60 h / Ambient temperature
2: 94 percent / Br2 / CH2Cl2 / 0.5 h / -78 °C
3: 46 percent / DBU / tetrahydrofuran / 48 h / 45 °C
4: 55 percent / Pd on charcoal / benzene / 15 h / Heating
View Scheme
参考文献
Aitken, R. Alan; Cadogen, J. I. G.; Gosney, Ian; Newlands, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 16 p. 2301 - 2308
参考文献
Cava; Deana
Journal of the American Chemical Society, 1959 , vol. 81, p. 4266
反应条件
1: 78 percent / NaSO2CH2OH, NaI / dimethylformamide / 22 h / Ambient temperature
2: 78 percent / benzene / 3 h / Heating
View Scheme
参考文献
Jarvis, William F.; Hoey, Michael D.; Finocchio, Alfred L.; Dittmer, Donald C.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5750 - 5756
反应条件
hydrogenchloride; sodium tetrahydroborate
1.) methanol, 0 deg C, 30 min; 2.) 50 deg C, 5 min; Yield given. Multistep reaction;
参考文献
Charlton, James L.; Durst, Tony
Tetrahedron Letters, 1984 , vol. 25, # 46 p. 5287 - 5290
参考文献
Uoyama, Hiroki; Chenxin, Cai; Tahara, Hiroyuki; Shimizu, Yusuke; Hagiwara, Hideki; Hanasaki, Yasuaki; Yamada, Hiroko; Okujima, Tetsuo; Unoa, Hidemitsu
Heterocycles, 2010 , vol. 80, # 2 p. 1187 - 1196
反应条件
diethyl benzenedicarboxylate
T=300°C;
参考文献
Cava; Deana
Journal of the American Chemical Society, 1959 , vol. 81, p. 4266
