1.1: aq. NH3 / 1 h / 25 °C 1.2: 187 mg / aq. NaOH / dioxane / 1 h / 25 °C 2.1: 161 mg / DCC; 1-hydroxybenzotriazole; Et3N / CH2Cl2; tetrahydrofuran / 17 h / 25 °C 3.1: 90.1 percent / H2 / Pd / methanol; H2O / 4 h / 25 °C / 2574.28 Torr View Scheme

1.1: aq. NH3 / 1 h / 25 °C 1.2: 187 mg / aq. NaOH / dioxane / 1 h / 25 °C 2.1: 161 mg / DCC; 1-hydroxybenzotriazole; Et3N / CH2Cl2; tetrahydrofuran / 17 h / 25 °C 3.1: 90.1 percent / H2 / Pd / methanol; H2O / 4 h / 25 °C / 2574.28 Torr View Scheme

1: With ammonium hydroxide T=25°C; ammonolysis; 1 h; 2: With sodium hydroxide in 1,4-dioxane T=25°C; Hydrolysis; 1 h;