6,7-二甲氧基-3,4-二氢-1H-2-萘酮合成路线 （共 28 条）
反应条件
boron trifluoride diethyl etherate
参考文献
EFFIPHARMA, INC.; MAILMAN, Richard, B.
Patent: WO2010/17093 A2, 2010 ;
Location in patent: Page/Page column 35 ;
反应条件
1: With potassium tert-butylate in diethyl ether Condensation; Dieckmann reaction; 0.5 h; 2: With hydrogenchloride; water; lithium chloride in dimethyl sulfoxide T=125°C; Hydrolysis; Decarboxylation; 5 h;
参考文献
Qandil, Amjad M.; Miller, David W.; Nichols, David E.
Synthesis, 1999 , # 12 p. 2033 - 2035
反应条件
DCN in water; acetonitrile 3 h; Irradiation;
参考文献
Tetrahedron Letters, , vol. 34, # 41 p. 6631 - 6634
反应条件
aluminium chloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
反应条件
(i) AlCl3, CH2Cl2, (ii) /BRN= 1730731/; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 21, # 8 p. 825 - 828
反应条件
1.1: 86 percent / ICl / CH2Cl2; acetic acid 2.1: 92 percent / SOCl2 / 20 °C 3.1: 96 percent / Et3N / [PdCl2(PPh3)2] / acetonitrile / 6 h / Heating 4.1: 100 percent / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr 5.1: KO-tert-Bu / diethyl ether / 0.5 h 5.2: 62 percent / LiCl; HCl; H2O / dimethylsulfoxide / 5 h / 125 °C View Scheme
参考文献
Synthesis, , # 12 p. 2033 - 2035
反应条件
1.1: 84 percent / H2 / Pd/C / ethanol 2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 2.2: tetrahydrofuran / 3 h / -78 - 20 °C 3.1: 74 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2867 - 2872
反应条件
1.1: aq. NaOH 2.1: 84 percent / H2 / Pd/C / ethanol 3.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 3.2: tetrahydrofuran / 3 h / -78 - 20 °C 4.1: 74 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 9 p. 2867 - 2872
反应条件
1.1: 92 percent / SOCl2 / 20 °C 2.1: 96 percent / Et3N / [PdCl2(PPh3)2] / acetonitrile / 6 h / Heating 3.1: 100 percent / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr 4.1: KO-tert-Bu / diethyl ether / 0.5 h 4.2: 62 percent / LiCl; HCl; H2O / dimethylsulfoxide / 5 h / 125 °C View Scheme
参考文献
Synthesis, , # 12 p. 2033 - 2035
反应条件
1.1: 96 percent / Et3N / [PdCl2(PPh3)2] / acetonitrile / 6 h / Heating 2.1: 100 percent / H2 / 10 percent Pd/C / ethanol / 2585.74 Torr 3.1: KO-tert-Bu / diethyl ether / 0.5 h 3.2: 62 percent / LiCl; HCl; H2O / dimethylsulfoxide / 5 h / 125 °C View Scheme
参考文献
Synthesis, , # 12 p. 2033 - 2035
