1: sodium tetrahydroborate / methanol / 3 h / 20 °C 2: sodium hydroxide / dichloromethane / 3 h / 0 - 20 °C 3: sodium hydride / tetrahydrofuran; acetonitrile; mineral oil 4: lithium aluminium tetrahydride / 5 °C / |Reflux 5: 5 palladium on charcoal; hydrogen / methanol / 16 h 6: CHIRALPAK AD-H column / |Resolution of racemate 7: 1H-imidazole / dichloromethane / 16 h / 0 - 5 °C 8: potassium carbonate / N,N-dimethyl-formamide / 2 h / 55 °C 9: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C View Scheme

1: sodium tetrahydroborate / methanol / 3 h / 20 °C 2: sodium hydroxide / dichloromethane / 3 h / 0 - 20 °C 3: sodium hydride / tetrahydrofuran; acetonitrile; mineral oil 4: lithium aluminium tetrahydride / 5 °C / |Reflux 5: 5 palladium on charcoal; hydrogen / methanol / 16 h 6: CHIRALPAK AD-H column / |Resolution of racemate 7: 1H-imidazole / dichloromethane / 16 h / 0 - 5 °C 8: pyridine / 3 h / 0 - 25 °C View Scheme