(R)-(+)-5’-甲氧基劳丹素合成路线 （共 4 条）
反应条件
1: 1-(3',4',5'-trimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline With sodium tetrahydroborate in 1,4-dioxane; ethanol T=100°C; 3.5 h; 2: formaldehyd With sodium phosphonate pentahydrate in 1,4-dioxane; ethanol; water T=80°C; 1.25 h;
参考文献
Vilhanova, Beata; Matousek, Vaclav; Vaclavik, Jiri; Syslova, Kamila; Prech, Jan; Pechacek, Jan; Sot, Petr; Januscak, Jakub; Toman, Jaromir; Zapal, Jakub; Kuzma, Marek; Kacer, Petr
Tetrahedron Asymmetry, 2013 , vol. 24, # 1 p. 50 - 55
反应条件
1.1: anhydrous xylene / 4 h / |Reflux; |Dean-Stark 2.1: trichlorophosphate / acetonitrile / 4 h / 100 °C / |Inert atmosphere 3.1: sodium tetrahydroborate / 1,4-dioxane; ethanol / 3.5 h / 100 °C 3.2: 1.25 h / 80 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 1 p. 50 - 55
反应条件
1.1: anhydrous xylene / 4 h / |Reflux; |Dean-Stark 2.1: trichlorophosphate / acetonitrile / 4 h / 100 °C / |Inert atmosphere 3.1: sodium tetrahydroborate / 1,4-dioxane; ethanol / 3.5 h / 100 °C 3.2: 1.25 h / 80 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 1 p. 50 - 55
反应条件
1.1: trichlorophosphate / acetonitrile / 4 h / 100 °C / |Inert atmosphere 2.1: sodium tetrahydroborate / 1,4-dioxane; ethanol / 3.5 h / 100 °C 2.2: 1.25 h / 80 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 1 p. 50 - 55
