2-(4-溴苯氧基)-N,N-二甲基乙胺合成路线 （共 21 条）
反应条件
sodium iodide; caesium carbonate in butanone
反应条件
sodium hydride; N,N-dimethyl-formamide T=85 - 90°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 9 p. 1056 - 1060
反应条件
1: 4-[2-(dimethylamino)-ethoxy]-bromobenzene With magnesium in tetrahydrofuran 1 h; Heating; 2: boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C;
参考文献
Zhou, Chengxiang; Larock, Richard C.
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3765 - 3777
反应条件
hydrogenchloride; ethylmagnesium bromide Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 9 p. 1056 - 1060
反应条件
hydrogenchloride; ethylmagnesium bromide Yield given. Multistep reaction;
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=100°C; 2 h; Microwave irradiation;
参考文献
UNIVERSITY HEALTH NETWORK; SAMPSON, Peter Brent; Ll, Sze-Wan; LIU, Yong; PAULS, Heinz W.; EDWARDS, Louise G.; FORREST, Bryan T.; FEHER, Miklos; PATEL, Narendra Kumar B.; PAN, Guohua
Patent: WO2010/115279 A1, 2010 ;
Location in patent: Page/Page column 187-188 ;
WO 2010/115279 A1
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water Suzuki-Miyaura cross-coupling; Heating;
参考文献
McKinley, Neola F.; O'Shea, Donal F.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9552 - 9555
反应条件
1.1: Mg / tetrahydrofuran / 1 h / Heating 1.2: 70 percent / tetrahydrofuran / -78 - 20 °C 2.1: 68 percent / K2CO3 / PdCl2(PhCN)2 / dimethylformamide; H2O / 24 h / 45 °C View Scheme
参考文献
Al-Hassan
Synthesis, 1987 , vol. No. 9, p. 816 - 817
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in tetrahydrofuran T=60°C; Suzuki-Miyaura coupling; 12 h; Inert atmosphere; optical yield given as percent de;
参考文献
Ishida, Naoki; Shimamoto, Yasuhiro; Murakami, Masahiro
Organic Letters, 2009 , vol. 11, # 23 p. 5434 - 5437
