2-(3,5-二溴-4-羟基苯基)乙酸合成路线 （共 8 条）
反应条件
bromine in acetic acid T=15°C; 96 h;
参考文献
Shestak; Novikov; Ivanova; Gorshkova
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 7 p. 366 - 369
反应条件
1: With Oxonereg;; sodium bromide in water; acetone T=20°C; 0.05 h; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; 14 h; 3: With acetic acid in tetrahydrofuran; water pH=3 - 4;
参考文献
Kang, Dong Wook; Kim, Yong Soo; Lim, Kwang Su; Kim, Myeong Seop; Pearce, Larry V.; Pavlyukovets, Vladimir A.; Tao, Andy K.; Lang-Kuhs, Krystle A.; Blumberg, Peter M.; Lee, Jeewoo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8092 - 8105
反应条件
bromine; urea 1.) AcOH, 60 h; 2.) 140 degC, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
D'Ambrosio; Guerriero; Pietra
Helvetica Chimica Acta, 1984 , vol. 67, # 6 p. 1484 - 1492
反应条件
bromine; urea 1.) AcOH, 60 h; 2.) 140 degC, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
D'Ambrosio; Guerriero; Pietra
Helvetica Chimica Acta, 1984 , vol. 67, # 6 p. 1484 - 1492
反应条件
1: 98 percent / H2SO4 / benzene / Heating 2: 68 percent / HNO3 / acetic acid / 10 - 15 °C View Scheme
参考文献
Gorshkov, B. A.; Shestak, O. P.; Gorshkova, I. A.; Makar'eva, T. N.; Novikov, V. L.; Stonik, V. A.
Chemistry of Natural Compounds, 1992 , vol. 28, # 1 p. 128 - 129
Khimiya Prirodnykh Soedinenii, 1992 , # 1 p. 149 - 151
反应条件
sulfuric acid in ethanol
参考文献
Syntex (U.S.A.) Inc.
Patent: US5284971 A1, 1994 ;
反应条件
sulfuric acid in benzene Heating;
参考文献
Shestak; Novikov; Ivanova; Gorshkova
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 7 p. 366 - 369
反应条件
sulfuric acid in benzene Heating;
参考文献
Shestak; Novikov; Ivanova; Gorshkova
Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 7 p. 366 - 369
