1-甲基-5-丙基-1H-吡唑-3-甲酸合成路线 （共 9 条）
反应条件
1: in methanol T=0 - 5°C; 2: With sulfuric acid T=85 - 90°C;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1: in dichloromethane Heating; 2: With sodium hydroxide in water 4 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1045 - 1050
反应条件
1.1: 70 percent / NaOEt / ethanol / 0 - 20 °C 2.1: CH2Cl2 / Heating 2.2: 40 percent / 5 percent aq. sodium hydroxide / H2O / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 5 p. 1045 - 1050
反应条件
sulfuric acid; nitric acid T=90 - 95°C;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C 2.1: SOCl2 2.2: 86 percent / NH4OH; water / 3 h / 20 °C 3.1: HCl; SnCl2; water / 20 °C 3.2: 90 percent / NaOH; water View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C 2.1: SOCl2 2.2: 86 percent / NH4OH; water / 3 h / 20 °C View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C
2.1: SOCl2
2.2: 86 percent / NH4OH; water / 3 h / 20 °C
3.1: HCl; SnCl2; water / 20 °C
3.2: 90 percent / NaOH; water
4.1: SOCl2 / 3 h / Heating
4.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C
2.1: SOCl2
2.2: 86 percent / NH4OH; water / 3 h / 20 °C
3.1: HCl; SnCl2; water / 20 °C
3.2: 90 percent / NaOH; water
4.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C
2.1: SOCl2
2.2: 86 percent / NH4OH; water / 3 h / 20 °C
3.1: HCl; SnCl2; water / 20 °C
3.2: 90 percent / NaOH; water
4.1: 30 percent / polyphosphoric acid / Heating
5.1: 92 percent / chlorosulfonic acid / 1 h / 65 - 70 °C
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
