1-甲基-4-硝基-5-丙基-1H-吡唑-3-羧酸合成路线 （共 8 条）
反应条件
sulfuric acid; nitric acid T=90 - 95°C;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
sulfuric acid; nitric acid T=90 - 95°C;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: methanol / 0 - 5 °C 1.2: 36 percent / H2SO4 / 85 - 90 °C 2.1: 78 percent / H2SO4; HNO3 / 90 - 95 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2 1.2: 86 percent / NH4OH; water / 3 h / 20 °C 2.1: HCl; SnCl2; water / 20 °C 2.2: 90 percent / NaOH; water View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1: With thionyl chloride 2: With ammonium hydroxide; water T=20°C; 3 h;
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2
1.2: 86 percent / NH4OH; water / 3 h / 20 °C
2.1: HCl; SnCl2; water / 20 °C
2.2: 90 percent / NaOH; water
3.1: SOCl2 / 3 h / Heating
3.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2
1.2: 86 percent / NH4OH; water / 3 h / 20 °C
2.1: HCl; SnCl2; water / 20 °C
2.2: 90 percent / NaOH; water
3.1: 30 percent / polyphosphoric acid / Heating
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
反应条件
1.1: SOCl2
1.2: 86 percent / NH4OH; water / 3 h / 20 °C
2.1: HCl; SnCl2; water / 20 °C
2.2: 90 percent / NaOH; water
3.1: 30 percent / polyphosphoric acid / Heating
4.1: 92 percent / chlorosulfonic acid / 1 h / 65 - 70 °C
View Scheme
参考文献
El-Abadelah, Mustafa M.; Sabri, Salim S.; Khanfar, Monther A.; Yasin, Hani A.; Voelter, Wolfgang
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 1055 - 1059
