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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1-萘丙胺
合成路线
（共 12 条）
220193-49-7
→
反应条件
24781-50-8
1-萘丙胺
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US6307090 B1, 2001 ;
US 6307090 B1
70067-70-8
→
反应条件
24781-50-8
1-萘丙胺
反应条件
borane-THF in tetrahydrofuran 3 h; Heating;
参考文献
Picard, I. le; Depreux, P.; Lesieur, I.; Delagrange, P.; Bennejean, C.; Renard, P.; Voisin, P.
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 183 - 188
111686-30-7
→
反应条件
24781-50-8
1-萘丙胺
反应条件
hydrogen; ammonia; nickel in methanol T=45°C; P=760 Torr; 20 h; Yield given;
参考文献
Furet, Pascal; Gay, Brigitte; Caravatti, Giorgio; Garcia-Echeverria, Carlos; Rahuel, Joseph; Schoepfer, Joseph; Fretz, Heinz
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3442 - 3449
773-99-9
2-(1-萘基)乙醇
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: Et3N / CH2Cl2 / 4 h / 0 °C 2: 73 percent / 18-crown-6 / acetonitrile / 18 h / Heating 3: H2; NH4OH / Raney nickel / ethanol / 24 h / 0 °C / 2585.74 Torr View Scheme
参考文献
Gardner, Richard Andrew; Delcros, Jean-Guy; Konate, Fanta; Breitbeil III, Fred; Martin, Benedicte; Sigman, Michael; Huang, Min; Phanstiel IV, Otto
Journal of Medicinal Chemistry, 2004 , vol. 47, # 24 p. 6055 - 6069
119744-43-3
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: 73 percent / 18-crown-6 / acetonitrile / 18 h / Heating 2: H2; NH4OH / Raney nickel / ethanol / 24 h / 0 °C / 2585.74 Torr View Scheme
参考文献
Gardner, Richard Andrew; Delcros, Jean-Guy; Konate, Fanta; Breitbeil III, Fred; Martin, Benedicte; Sigman, Michael; Huang, Min; Phanstiel IV, Otto
Journal of Medicinal Chemistry, 2004 , vol. 47, # 24 p. 6055 - 6069
98978-43-9
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: 98 percent / H2 / 10 percent Pd/C / aq. ethanol / Ambient temperature 2: 100 percent / LiAlH4 / diethyl ether / Ambient temperature 3: Et3N / CH2Cl2 / 2.5 h / 0 - 20 °C 4: NaN3 / dimethylformamide / 3 h / 90 °C 5: 100 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Yao, Zhu-Jun; King, Richter C.; Cao, Tin; Kelley, James; Milne, George W. A.; Voigt, Johannes H.; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 25 - 35
66-77-3
1-萘甲醛
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: 1.) NaH / 1.) ether, 0 deg C, 1 h, 2.) ether, RT, 8 h 2: 98 percent / H2 / 10 percent Pd/C / aq. ethanol / Ambient temperature 3: 100 percent / LiAlH4 / diethyl ether / Ambient temperature 4: Et3N / CH2Cl2 / 2.5 h / 0 - 20 °C 5: NaN3 / dimethylformamide / 3 h / 90 °C 6: 100 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Yao, Zhu-Jun; King, Richter C.; Cao, Tin; Kelley, James; Milne, George W. A.; Voigt, Johannes H.; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 25 - 35
36818-50-5
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: 100 percent / LiAlH4 / diethyl ether / Ambient temperature 2: Et3N / CH2Cl2 / 2.5 h / 0 - 20 °C 3: NaN3 / dimethylformamide / 3 h / 90 °C 4: 100 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Yao, Zhu-Jun; King, Richter C.; Cao, Tin; Kelley, James; Milne, George W. A.; Voigt, Johannes H.; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 25 - 35
20849-45-0
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1: NaN3 / dimethylformamide / 3 h / 90 °C 2: 100 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Yao, Zhu-Jun; King, Richter C.; Cao, Tin; Kelley, James; Milne, George W. A.; Voigt, Johannes H.; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 1 p. 25 - 35
90-14-2
1-碘萘
→
反应条件
24781-50-8
1-萘丙胺
反应条件
1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 20 °C 1.2: NaOH / Cl2Pd(PPh3)2 / tetrahydrofuran / 1.5 h / 20 °C 2.1: CF3COOH / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Nomura, Takashi; Iwaki, Tsutomu; Yasukata, Tatsuro; Nishi, Koichi; Narukawa, Yukitoshi; Uotani, Koichi; Hori, Toshihiko; Miwa, Hideaki
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6615 - 6628
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