3-(4-(苄氧基)苯基)丙酸甲酯合成路线 （共 24 条）
反应条件
lithium hydroxide; water in tetrahydrofuran T=20°C; 2 h;
参考文献
Bristol-Myers Squibb Company
Patent: US6414179 B1, 2002 ;
反应条件
1: 76.6 percent / LiAlH4 / diethyl ether / 2.5 h / Ambient temperature 2: 45.3 percent / Ag2CO3-celite / benzene / Heating 3: 100 percent / H2 / 10percent Pd-C / methanol / 760 Torr / Ambient temperature View Scheme
参考文献
Herbert, Richard B.; Kattah, Abdullah E.
Tetrahedron, 1990 , vol. 46, # 20 p. 7105 - 7118
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; pH=2;
参考文献
CRYSTAX PHARMACEUTICALS, S.L.; AYMAMI BOFARULL, Juan; MARTINELL PEDEMONTE, Marc; CASTRO-PALOMINO LARIA, Julio; NICOLAS CHEVALIER, Franck Camille; VALLS VIDAL, Nuria
Patent: WO2010/70076 A1, 2010 ;
Location in patent: Page/Page column 105 ;
反应条件
1: 1.305 g / LiAlH4 / diethyl ether; tetrahydrofuran / 1.) room temperature, 1 h, 2.) reflux, 1 h 2: 0.149 g / H2 / 10percent Pd-charcoal / ethanol / Ambient temperature View Scheme
参考文献
Ishii, Hisashi; Ishikawa, Tsutomu; Tohojoh, Toshiaki; Murakami, Keiko; Kawanable, Eri; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 9 p. 2051 - 2058
反应条件
in N,N-dimethyl-formamide
参考文献
Bristol-Myers Squibb Company
Patent: US6414179 B1, 2002 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 76 ;
EP 1688138 A1
反应条件
[2,2']bipyridinyl; hydrogen; palladium on activated charcoal in methanol
T=20°C; 5 h;
参考文献
Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996
反应条件
diazomethyl-trimethyl-silane
T=25°C; 16 h;
参考文献
BOGER, Dale, L.
Patent: WO2008/147553 A1, 2008 ;
Location in patent: Page/Page column 39 ;
WO 2008/147553 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=120°C; 18 h;
参考文献
Lewin, Anita H.; Szewczyk, Jerzy; Wilson, Joseph W.; Carroll, F. Ivy
Tetrahedron, 2005 , vol. 61, # 30 p. 7144 - 7152
反应条件
1.1: 99 percent / H2 / Pd/C / ethyl acetate / 20 °C
2.1: NaH / dimethylformamide / 0.17 h / 0 °C
2.2: 72 percent / dimethylformamide / 20 °C
3.1: methanol / 16 h / 25 °C
View Scheme
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
