甲基 3-氨基-2,4-二甲基苯甲酸合成路线 （共 3 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol 144 h;
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
Location in patent: Page/Page column 17; 18 ;
反应条件
1: iodine; periodic acid / sulfuric acid; acetic acid / 168 h / 90 °C 2: palladium diacetate; 1,4-di(diphenylphosphino)-butane; triethylamine / acetonitrile / 2 h / 100 °C / 4137.41 Torr / |Autoclave; |Sealed tube 3: palladium 10 on activated carbon; hydrogen / methanol / 144 h View Scheme
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
反应条件
1: palladium diacetate; 1,4-di(diphenylphosphino)-butane; triethylamine / acetonitrile / 2 h / 100 °C / 4137.41 Torr / |Autoclave; |Sealed tube 2: palladium 10 on activated carbon; hydrogen / methanol / 144 h View Scheme
参考文献
ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee
Patent: WO2014/4230 A1, 2014 ;
