3-氨基-4-乙基苯甲酸甲酯合成路线 （共 9 条）
反应条件
hydrogen; palladium in methanol
参考文献
LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon
Patent: WO2014/73904 A1, 2014 ;
Location in patent: Paragraph 1161-1164 ;
反应条件
hydrogenchloride in methanol; water
参考文献
Merck and Co., Inc.
Patent: US5631280 A1, 1997 ;
US 5631280 A
反应条件
1.1: acetyl chloride / 0.17 h / 20 °C 1.2: 6 h / |Reflux 2.1: palladium 10 on activated carbon; ammonium formate / methanol / 1.5 h / |Inert atmosphere; |Reflux View Scheme
参考文献
QUANTICEL PHARMACEUTICALS, INC; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan
Patent: WO2014/89364 A1, 2014 ;
反应条件
1.1: potassium permanganate; sodium hydroxide / water / 2.5 h / |Reflux 2.1: acetyl chloride / 0.17 h / 20 °C 2.2: 6 h / |Reflux 3.1: palladium 10 on activated carbon; ammonium formate / methanol / 1.5 h / |Inert atmosphere; |Reflux View Scheme
参考文献
GALAPAGOS NV; MENET, Christel; SCHMITT, Benoît; GENEY, Raphaël; DOYLE, Kevin; PEACH, Joanne; PALMER, Nicholas; JONES, Graham; HARDY, David; DUFFY, James
Patent: WO2013/117649 A1, 2013 ;
反应条件
1: sulfuric acid; nitric acid / 2 h / 0 °C 2: hydrogenchloride / 20 h / |Reflux 3: palladium; hydrogen / methanol View Scheme
参考文献
QUANTICEL PHARMACEUTICALS, INC; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan
Patent: WO2014/89364 A1, 2014 ;
反应条件
2: aq. KOH View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 52, p. 597 - 609
反应条件
2,6-dimethylpyridine in benzene
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 74 percent / 2,6-lutidine / benzene
2: 85 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
反应条件
1: 74 percent / 2,6-lutidine / benzene
2: 85 percent / NaH / dimethylformamide; CH2Cl2 / Ambient temperature
3: 55 percent / water, NaOH / pyridine; methanol / 24 h / Heating
View Scheme
参考文献
Zrihen; Labia; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 307 - 314
