2,6-双(三氟甲基)苯甲酸合成路线 （共 6 条）
反应条件
potassium tert-butylate; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-75°C; 2 h;
参考文献
Schlosser, Manfred; Mongin; Porwisiak, Jacek; Dmowski, Wojciech; Bueker, Heinz H.; Nibbering, Nico M. M.
Chemistry - A European Journal, 1998 , vol. 4, # 7 p. 1281 - 1286
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 13, # 10 p. 1979 - 1985
Zhurnal Organicheskoi Khimii, , vol. 13, # 10 p. 2129 - 2135
反应条件
potassium hydroxide; sulfur(IV) fluoride; hydrogen fluoride 1.) 80 deg C, 20 h; 180 deg C, 20 h, 2.) 100 deg C, 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Fluorine Chemistry, , vol. 82, # 2 p. 163 - 165
反应条件
2,2,6,6-tetramethyl-piperidine; n-butyllithium 1.) THF, -78 deg C, 1.5 h, 2.) THF; Yield givenMultistep reaction. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 55, # 4 p. 909 - 918
反应条件
1: 78.5 percent / SF4 / 20 h / 90 °C 2: 72.5 percent / LiAlH4 / diethyl ether / 0 - 15 °C View Scheme
参考文献
Roussel Uclaf
Patent: US5504112 A1, 1996 ;
反应条件
sodium hydrogencarbonate in tetrahydrofuran
参考文献
Roussel-UCLAF
Patent: US5340835 A1, 1994 ;
