N-甲氧基-n-甲基-3-环戊烯-1-羧酰胺合成路线 （共 8 条）
反应条件
1: 3-cyclopentene-1-carboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane
0.75 h;
2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane
参考文献
Coe, Jotham W.; Bianco, Krista E.; Boscoe, Brian P.; Brooks, Paige R.; Cox, Eric D.; Vetelino, Michael G.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9964 - 9970
反应条件
1: With n-butyllithium; 2-Bromo-1,3,5-trimethyl-benzene in tetrahydrofuran; pentane
T=-78°C; 1.5 h;
2: 2-methoxy-pyridine in tetrahydrofuran; pentane
T=-78 - 20°C; 2.08333 h;
3: cyclopent-3-enecarboxylic acid methoxy-methyl-amide in tetrahydrofuran; pentane
T=-78 - 20°C; 18.0833 h;
参考文献
Pfizer Inc
Patent: US2005/20830 A1, 2005 ;
Location in patent: Page 22 ;
反应条件
mesityllithium in tetrahydrofuran
T=-78°C;
参考文献
Demers, Sebastien; Stevenson, Heather; Candler, John; Bashore, Crystal G.; Arnold, Eric P.; O'Neill, Brian T.; Coe, Jotham W.
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3368 - 3371
反应条件
1: 2-fluoro-3-iodopyridine With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C; 1.16667 h;
2: cyclopent-3-enecarboxylic acid methoxy-methyl-amide in tetrahydrofuran; hexane
T=-78°C; 3.25 h;
参考文献
Pfizer Inc
Patent: US2005/20830 A1, 2005 ;
Location in patent: Page 24 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
Demers, Sebastien; Stevenson, Heather; Candler, John; Bashore, Crystal G.; Arnold, Eric P.; O'Neill, Brian T.; Coe, Jotham W.
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3368 - 3371
反应条件
1: 2-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.166667 h;
2: cyclopent-3-enecarboxylic acid methoxy-methyl-amide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Coe, Jotham W.; Bianco, Krista E.; Boscoe, Brian P.; Brooks, Paige R.; Cox, Eric D.; Vetelino, Michael G.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 9964 - 9970
反应条件
n-butyllithium in tetrahydrofuran
T=-78 - 20°C;
参考文献
Coe, Jotham W.; Vetelino, Michael G.; Bashore, Crystal G.; Wirtz, Michael C.; Brooks, Paige R.; Arnold, Eric P.; Lebel, Lorraine A.; Fox, Carol B.; Sands, Steven B.; Davis, Thomas I.; Schulz, David W.; Rollema, Hans; Tingley III, F. David; O'Neill, Brian T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2974 - 2979
反应条件
1: n-BuLi / tetrahydrofuran / -78 - 20 °C
2: BCl3 / CH2Cl2
View Scheme
参考文献
Coe, Jotham W.; Vetelino, Michael G.; Bashore, Crystal G.; Wirtz, Michael C.; Brooks, Paige R.; Arnold, Eric P.; Lebel, Lorraine A.; Fox, Carol B.; Sands, Steven B.; Davis, Thomas I.; Schulz, David W.; Rollema, Hans; Tingley III, F. David; O'Neill, Brian T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 2974 - 2979
