5-氯-1,2-二氢-4-羟基-1-甲基-2-氧代-3-喹啉羧酸乙酯合成路线 （共 10 条）
反应条件
1: With sodium hydride in N,N-dimethyl-formamide T=0 - 85°C; 5 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
Tomassoli, Isabelle; Ismaili, Lhassane; Pudlo, Marc; De Los Rios, Cristobal; Soriano, Elena; Colmena, Ines; Gandia, Luis; Rivas, Luis; Samadi, Abdelouahid; Marco-Contelles, Jose; Refouvelet, Bernard
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 1 - 10
反应条件
hydrogenchloride in methanol; N,N-dimethyl acetamide; water
参考文献
Active Biotech AB
Patent: US6133285 A1, 2000 ;
反应条件
1: 5-chloro-2H-3,1-benzoxazine-2,4(1H)-dione; methyl iodide With sodium hydride in isobutyramide T=0 - 20°C; 5 h; 2: diethyl malonate With sodium hydride in isobutyramide T=85°C; 5 h; 3: With hydrogenchloride in methanol; isobutyramide; water T=20°C;
参考文献
Active Biotech AB
Patent: EP1095021 B1, 2003 ;
Location in patent: Page/Page column 6 ;
反应条件
1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
water; trifluoroacetic acid in dimethyl sulfoxide; acetonitrile T=50°C; 2 h; Kinetics; Further Variations:Reagents;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
反应条件
hydrogenchloride in acetic acid T=60°C; 6 h;
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/55072 A1, 2010 ;
US 20100055072 A1
反应条件
1: 0.1 h / 100 °C / microwave irradiation 2: 98 percent / heptane / 6.58 h / Heating View Scheme
参考文献
Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088
反应条件
T=100°C; 0.1 h; microwave irradiation;
参考文献
Jansson, Karl; Fristedt, Tomas; Olsson, Arne; Svensson, Bo; Joensson, Stig
Journal of Organic Chemistry, 2006 , vol. 71, # 4 p. 1658 - 1667
