(S)-2,6-二叔丁氧羰基氨基己酸合成路线 (共 19 条)
反应条件
1: Py 2: aq. NaOH View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 94, p. 743 - 759
反应条件
1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C 2: hydrogen bromide; acetic acid / 2 h / 20 °C 3: Pseudomonas aeruginosa ORF PA0919; p-Nitrophenyl Phosphate / dimethyl sulfoxide; aq. phosphate buffer / 22 °C / pH 6.8 View Scheme
参考文献
Arendt, Wiebke; Groenewold, Maike K.; Hebecker, Stefanie; Dickschat, Jeroen S.; Moser, Juergen
Journal of Biological Chemistry, 2013 , vol. 288, # 34 p. 24717 - 24730
反应条件
1: 100 percent / pyridine 2: 90 percent / H2 / 10percent Pd-C / ethyl acetate View Scheme
参考文献
Ogura, Haruo; Takeda, Kazuyoshi
Heterocycles, 1981 , vol. 15, # 1 p. 467 - 468
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Wang, Hangxiang; Koshi, Yoichiro; Minato, Daishiro; Nonaka, Hiroshi; Kiyonaka, Shigeki; Mori, Yasuo; Tsukiji, Shinya; Hamachi, Itaru
Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 12220 - 12228
参考文献
Ogura, Haruo; Takeda, Kazuyoshi
Heterocycles, 1981 , vol. 15, # 1 p. 467 - 468
参考文献
Ogura, Haruo; Takeda, Kazuyoshi
Heterocycles, 1981 , vol. 15, # 1 p. 467 - 468
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C;
参考文献
Arendt, Wiebke; Groenewold, Maike K.; Hebecker, Stefanie; Dickschat, Jeroen S.; Moser, Juergen
Journal of Biological Chemistry, 2013 , vol. 288, # 34 p. 24717 - 24730
反应条件
1: 4.7 g / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH2Cl2 / 3 h
2: 16 g / 5N HCl-ethanol / CHCl3 / 0.83 h
View Scheme
参考文献
Mori; Nishimura; Tamaki; Nakamura; Tsuda; Kakeya
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 338 - 344
反应条件
1: 1.) 1-hydroxybenzotriazole hydrate, CDI / 1.) THF, 2.) THF, RT, overnight
2: 1N aq. HCl / 2 h / Heating
View Scheme
参考文献
Leschke, Christian; Storm, Ruediger; Breitweg-Lehmann, Evelyn; Exner, Torsten; Nuernberg, Bernd; Schunack, Walter
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3130 - 3139