N-叔丁氧羰基-L-丙氨酸 4-硝基苯酯合成路线 （共 14 条）
反应条件
1: 58 percent / NaOH / dioxane; H2O
2: 78 percent / dicyclohexylamine / dimethylformamide / 2 h / Heating
View Scheme
参考文献
Zaoral, Milan; Jezek, Jan; Krchnak, Viktor; Straka, Radovan
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 5 p. 1424 - 1446
反应条件
1: Z-(s,S)-isoleucine With Ca(OH)2 in water
T=20°C;
2: 4-nitrophenyl N-Boc-L-alanine ester in N,N-dimethyl-formamide
T=25°C; 24 h;
参考文献
Hashimoto, Chikao; Takeguchi, Kazunobu; Kodomari, Mitsuo
Synlett, 2011 , # 10 art. no. U01811ST, p. 1427 - 1430
反应条件
(i) Et3N, CH2Cl2, (ii) HCl, AcOH, (iii) /BRN= 746197/, Et3N, CH2Cl2; Multistep reaction;
参考文献
Delalande
Patent: DE2806833 , 1978 ;
Chem.Abstr., 1979 , vol. 90, # 72447
反应条件
phosphate buffer solution
T=25°C; Hydrolysis; pH=6.0; Kinetics; Further Variations:pH-valuesReagentsconcentration;
参考文献
Tsutsumi, Hiroshi; Hamasaki, Keita; Mihara, Hisakazu; Ueno, Akihiko
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 9 p. 1813 - 1818
