甲基N-[(苄氧基)羰基]-L-丙氨酰-L-丙氨酸酯合成路线 （共 21 条）
反应条件
1: 100 percent / 2 N HCl, H2 / Pd / methanol 2: 84 percent / NEt3, ethyl chlorocarbonate / tetrahydrofuran; dimethylformamide / 1.) -10 deg C, pH 7.5, 1h; 2.) 4 deg C, overnight 3: 100 percent / 2 N HCl, H2 / Pd / methanol 4: pyridine / 3 h / Ambient temperature View Scheme
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
1: 100 percent / 2 N HCl, H2 / Pd / methanol 2: 90 percent / pyridine / 3 h / Ambient temperature View Scheme
参考文献
Jahreis, Guenther; Fittkau, Siegfried
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 35 - 40
反应条件
triethylamine in toluene
T=-14°C; 1 h;
参考文献
Joshi, Kiran; Bao, Jiang; Goldman, Alan S.; Kohn, Joachim
Journal of the American Chemical Society, 1992 , vol. 114, # 17 p. 6649 - 6652
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine; trichlorophosphate in dichloromethane
T=20°C; 2 h;
参考文献
Chen, Hu; Xu, Xunfu; Liu, Liu; Tang, Guo; Zhao, Yufen
RSC Advances, 2013 , vol. 3, # 37 p. 16247 - 16250
反应条件
N-[2-(4-sulphonatephenylamino)-4-methoxy-1,3,5-triazin-6-yl]-4-methylmorpholinium inner salt; sodium hydrogencarbonate in water
5 h; Product distribution / selectivity;
参考文献
Politechnika Lódzka
Patent: EP2407460 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
TEA in dichloromethane; N,N-dimethyl-formamide
参考文献
Mital, Alka; Srivastava, Nivedita; Kumar, Arvind
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 12 p. 1129 - 1130
反应条件
1: tetrahydrofuran / 0 °C
2: 0.607 g / 4-methylmorpholine / tetrahydrofuran / 16 h / 0 - 20 °C
View Scheme
参考文献
Markowicz, Marcin W.; Dembinski, Roman
Synthesis, 2004 , # 1 p. 80 - 86
反应条件
2,6-dimethylpyridine; cation radical salt of tris(4-bromophenyl)aminium hexachloroantimonate in dichloromethane
0.8 h;
参考文献
Reischl, Gerald; El-Mobayed, Medhat; Beisswenger, Rudolf; Regier, Klaus; Maichle-Moessmer, Caecilia; Rieker, Anton
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1998 , vol. 53, # 7 p. 765 - 773
反应条件
1: 1.) 4N NaOH / 1.) ca. 5 deg C, 15 min 2.) ethyl acetate, Et2O, 5 min
2: 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 2 h / temperature: below 0 deg C
View Scheme
参考文献
Hoogwater, D. A.; Peereboom, M.
Tetrahedron, 1990 , vol. 46, # 15 p. 5325 - 5332
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane
2 h; temperature: below 0 deg C;
参考文献
Hoogwater, D. A.; Peereboom, M.
Tetrahedron, 1990 , vol. 46, # 15 p. 5325 - 5332
