7-甲氧基-1,2,3,4-四氢-萘-2-羧酸合成路线 （共 5 条）
反应条件
1: With methanol; sodium hydroxide; water 3 h; 2: With hydrogenchloride; water pH=1;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2007/67444 A1, 2007 ;
Location in patent: Page/Page column 152 ;
WO 2007/067444 A1
反应条件
sulfuric acid; hydrogen; palladium on activated charcoal in acetic acid T=80°C; 12 h;
参考文献
Yanagi; Kikuchi; Takeuchi; Ishikawa; Nishimura; Kamijo; Yamamoto
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 3 p. 340 - 344
反应条件
1.1: ethyl acetate / 1 h / Heating 1.2: AlCl3 / chlorobenzene / 2 h / 20 °C 2.1: 88 percent / H2; H2SO4 / 10 percent Pd/C / acetic acid / 12 h / 80 °C View Scheme
参考文献
Yanagi; Kikuchi; Takeuchi; Ishikawa; Nishimura; Kamijo; Yamamoto
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 3 p. 340 - 344
反应条件
1.1: NaOMe / methanol / 6.5 h / Heating 2.1: 5M aq. NaOH / methanol / Heating 3.1: 82 percent / H2 / 10 percent Pd/C / ethanol / 7 h / 20 °C 4.1: ethyl acetate / 1 h / Heating 4.2: AlCl3 / chlorobenzene / 2 h / 20 °C 5.1: 88 percent / H2; H2SO4 / 10 percent Pd/C / acetic acid / 12 h / 80 °C View Scheme
参考文献
Yanagi; Kikuchi; Takeuchi; Ishikawa; Nishimura; Kamijo; Yamamoto
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 3 p. 340 - 344
反应条件
hydrogenchloride; pyridine hydrochloride in ethyl acetate
参考文献
G.D. Searle and Co.
Patent: EP300404 A3, 1990 ;
