5-(3-氨基-4-氯-苯基)-6-乙基-嘧啶-2,4-二胺合成路线 （共 11 条）
反应条件
sodium tungstate; dihydrogen peroxide in methanol 12 h; Ambient temperature;
参考文献
Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 22 p. 3311 - 3318
反应条件
1: 1.) NaNO2, 5M aq. HCl; 2.) NaN3 / 1.) 0 deg C; 2.) 0 deg C, 2 h 2: 85 percent / 98percent hydrazine hydrate / 0.25 h / Heating View Scheme
参考文献
Threadgill, Michael D.; Gledhill, Adrian P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 873 - 876
反应条件
pyridine T=95°C; 3 h;
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
1: 80 percent / acetic acid / 1 h / 100 °C 2: ZnCl2 / ethanol / Ambient temperature View Scheme
参考文献
Griffin, Roger J.; Lowe, Philip R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 14 p. 1811 - 1820
反应条件
1.) reflux, 4 h; 2.) EtOH, 25 deg C, 4 weeks;
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
tin(ll) chloride in hydrogenchloride
T=5 - 10°C; Yield given;
参考文献
Griffin, Roger J.; Schwalbe, Carl H.; Stevens, Malcolm F. G.; Wong, Kait P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2267 - 2276
反应条件
in hydrogenchloride; ethanol; water
参考文献
FMC Corporation
Patent: US5521192 A1, 1996 ;
反应条件
sodium hydrogensulfide in water
T=65°C;
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
反应条件
hydrogenchloride in ethanol
T=60°C; 12 h;
参考文献
Griffin, Roger J.; Lowe, Philip R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 14 p. 1811 - 1820
反应条件
1: 95 percent / nitric acid (d=1.42), cc. H2SO4 / 1 h / 50 °C
2: SnCl2*2H2O / ethanol / Heating
View Scheme
参考文献
Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228
