4-氨基-3-甲氧基苯甲酸合成路线 （共 25 条）
反应条件
hydrogenchloride in ethanol; water
48 h; Inert atmosphereReflux;
参考文献
Budin, Ghyslain; Yang, Katherine S.; Reiner, Thomas; Weissleder, Ralph
Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9378 - 9381
反应条件
1: 73 percent / NaNO2; TMS-Br; PhCH2NEt3Br / dimethylformamide / 2 h / 0 °C
2: 86 percent / CDI; DMAP / dimethylformamide / 20 °C
View Scheme
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1.1: 73 percent / NaNO2; TMS-Br; PhCH2NEt3Br / dimethylformamide / 2 h / 0 °C
2.1: 86 percent / CDI; DMAP / dimethylformamide / 20 °C
3.1: t-BuLi / tetrahydrofuran / 1 h / -100 °C
3.2: 42 percent / aq. HCl / tetrahydrofuran / 0.17 h
View Scheme
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1.1: 73 percent / NaNO2; TMS-Br; PhCH2NEt3Br / dimethylformamide / 2 h / 0 °C
2.1: 86 percent / CDI; DMAP / dimethylformamide / 20 °C
3.1: t-BuLi / tetrahydrofuran / 1 h / -100 °C
3.2: 42 percent / aq. HCl / tetrahydrofuran / 0.17 h
4.1: 90 percent / aq. NaOH / 2 h / Heating
View Scheme
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1: EDC; Et3N / dimethylformamide / 12 h / 20 °C
2: LiAlH4 / tetrahydrofuran / 1 h / 0 °C
View Scheme
参考文献
Li, Gaoquan; Hasvold, Lisa A.; Tao, Zhi-Fu; Wang, Gary T.; Gwaltney II, Stephen L.; Patel, Jyoti; Kovar, Peter; Credo, Robert B.; Chen, Zehan; Zhang, Haiying; Park, Chang; Sham, Hing L.; Sowin, Thomas; Rosenberg, Saul H.; Lin, Nan-Horng
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 8 p. 2293 - 2298
