4-氨基-3-甲基苯甲酸合成路线 （共 35 条）
反应条件
1: With hydrogen bromide in water T=25°C; 1 h; 2: With sodium nitrate in water T=-2 - -1°C; 1.75 h; 3: With hydrogen bromide; copper(I) bromide in water T=-2 - 70°C; 2 h;
参考文献
NICHOLAS PIRAMAL INDIA LIMITED
Patent: WO2006/51477 A2, 2006 ;
Location in patent: Page/Page column 54 ;
反应条件
ethanol; HNO2 Diazotization.Kochen der Diazoverbindung mit konz. Salzsaeure;
参考文献
Beilstein; Kreusler
Justus Liebigs Annalen der Chemie, 1867 , vol. 144, p. 182
反应条件
1.1: sulfuric acid / 3 h / |Reflux 2.1: potassium acetate / chloroform / 1 h 2.2: 21 h / |Reflux 3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 3.2: 20 °C View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: aqueous hydrochloric acid / Diazotization 2: aqueous KOH-solution View Scheme
参考文献
Fichter; Schetty
Helvetica Chimica Acta, 1937 , vol. 20, p. 563,564
反应条件
1.1: thionyl chloride / dichloromethane / 3 h / 80 °C 2.1: hydrogenchloride; sodium nitrite; NH4BF4 / water / 0.58 h 2.2: 2 h / 20 °C 3.1: sodium hydroxide; water / methanol / 14 h / 60 °C 3.2: pH 6 View Scheme
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
US 20120277224 A1
反应条件
1.1: sulfuric acid / 3 h / |Reflux 2.1: potassium acetate / chloroform / 1 h 2.2: 21 h / |Reflux 3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 3.2: 20 °C View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
sodium hydrogencarbonate in ethyl acetate
参考文献
Cancer Research Campaign Technology Limited
Patent: US6034246 A1, 2000 ;
参考文献
Shi, Dong-Fang; Bradshaw, Tracey D.; Wrigley, Samantha; McCall, Carol J.; Lelieveld, Peter; Fichtner, Iduna; Stevens, Malcolm F. G.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 17 p. 3375 - 3384
反应条件
sulfuric acid RefluxInert atmosphere;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 39 ;
US 20120277224 A1
参考文献
Szczepankiewicz; Chiou; Credo; Alder; Nukkala; Zielinski; Jarvis; Mollison; Frost; Bauch; Hui; Liu; Claiborne; Li; Rosenberg; Jae; Tasker; Gunawardana; Von Geldern; Gwaltney II; Wu-Wong; Gehrke
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4416 - 4430
