4-氨基-3-甲基苯甲酸合成路线 （共 35 条）
反应条件
1.1: sulfuric acid / 3 h / |Reflux 2.1: potassium acetate / chloroform / 1 h 2.2: 21 h / |Reflux View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
1: SOCl2 / 2 h / 20 °C 2: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 3: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 4: 60 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
1.1: sulfuric acid / 3 h / |Reflux
2.1: potassium acetate / chloroform / 1 h
2.2: 21 h / |Reflux
View Scheme
参考文献
Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki
Patent: US2013/79306 A1, 2013 ;
反应条件
in tetrahydrofuran
Inert atmosphereReflux;
参考文献
Murphy, Natasha S.; Prabhakaran, Panchami; Azzarito, Valeria; Plante, Jeffrey P.; Hardie, Michaele J.; Kilner, Colin A.; Warriner, Stuart L.; Wilson, Andrew J.
Chemistry - A European Journal, 2013 , vol. 19, # 18 p. 5546 - 5550
反应条件
acetic anhydride; triethylamine in dichloromethane
参考文献
Chaturvedula, Prasad V.; Chen, Ling; Civiello, Rita; Conway, Charles Mark; Degnan, Andrew P.; Dubowchik, Gene M.; Han, Xiaojun; J. Jiang, Xiang Jun; Karageorge, George N.; Luo, Guanglin; Macor, John E.; Poindexter, Graham; Tora, George; Vig, Shikha
Patent: US2004/204397 A1, 2004 ;
US 20040204397 A1
