反应条件
1.1: sodium tetrahydroborate; iodine / tetrahydrofuran; methanol / 2 h / 0 - 5 °C / |Reflux 2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C 3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere 4.1: tert-butylmagnesium bromide; copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.25 h / -20 - -5 °C / |Inert atmosphere 4.2: 0.08 h 5.1: methyl iodide; water / methanol / 0.5 h / 20 °C / |Cooling with ice 6.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C View Scheme
参考文献
ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.; Pan, Xianhua; Li, Weijin; Zhang, Qunhui; Ruan, Libo; Yu, Wansheng; Deng, Fei; Ma, Tianhua; Huang, Mingwang; He, Minhuan
Patent: US2013/281695 A1, 2013 ;