(9aS)-八氢-4H-吡啶并[1,2-a]吡嗪-4-酮合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol T=20°C; Hydrolysis; deacylation; 0.5 h;
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: 96 percent / dioxane; H2O / 0.25 h / 20 °C 2: 84 percent / hydrogen / Pd/C / methanol / 4 h 3: 87 percent / aq. NaOH / CH2Cl2 / 3 h / 20 °C 4: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 5: HCl / methanol / 0.5 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: 84 percent / hydrogen / Pd/C / methanol / 4 h 2: 87 percent / aq. NaOH / CH2Cl2 / 3 h / 20 °C 3: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 4: HCl / methanol / 0.5 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: 87 percent / aq. NaOH / CH2Cl2 / 3 h / 20 °C 2: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 3: HCl / methanol / 0.5 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
1: 68 percent / NaH / tetrahydrofuran / 3 h / 20 °C 2: HCl / methanol / 0.5 h / 20 °C View Scheme
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Reduction; 2 h;
参考文献
Froelich, Olivier; Cossart, Francoise; Bonin, Martine; Quirion, Jean-Charles; Husson, Henri-Philippe
Heterocycles, 1999 , vol. 51, # 9 p. 2065 - 2072
