2-溴-4'-羟基苯乙酮合成路线 （共 52 条）
反应条件
1: 85 percent / methanol / 0.5 h / Heating 2: 80 percent / NaOH / dimethylformamide / 2 h / Heating 3: 67 percent / aq. HCl / acetone / 2 h / Heating 4: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min 5: 40 percent / NH4Cl / 24 h 6: 95 percent / NaBH4 / methanol / 90 h View Scheme
参考文献
Shetty, H. Umesha; Nelson, Wendel L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 55 - 59
反应条件
in tetrahydrofuran T=-78°C; 0.5 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1373 - 1380
反应条件
in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Crombie, Leslie; Hardy, Robert; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1373 - 1380
反应条件
in tetrahydrofuran 2 h; Ambient temperaturevariation of conditions; other halogenoacetophenones also investigated; Product distributionMechanism;
参考文献
Crombie, Leslie; Hardy, Robert; Knight, David W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1373 - 1380
反应条件
(i) hexamethylenetetramine, (ii) aq. HCl, (iii) NaBH4; Multistep reaction;
参考文献
Chatterjee,A. et al.
Journal of the Chemical Society, 1961 , p. 4576 - 4579
反应条件
1: 85 percent / methanol / 0.5 h / Heating 2: 80 percent / NaOH / dimethylformamide / 2 h / Heating 3: 67 percent / aq. HCl / acetone / 2 h / Heating 4: 1.) TsCl, 2.) NaH / 1.) pyridine, 0 deg C, 4 d, 2.) reflux, 90 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59
反应条件
1,4-diaza-bicyclo[2.2.2]octane in tetrahydrofuran T=20°C; 0.583333 h;
参考文献
Meshram; Santosh Kumar; Ramesh; Chennakesava Reddy
Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2580 - 2585
反应条件
in methanol 0.5 h; Heating;
参考文献
Shetty, H. Umesha; Nelson, Wendel L.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 55 - 59
反应条件
sodium hydroxide in methanol
参考文献
Hoechst Celanese Corporation
Patent: US5107034 A1, 1992 ;
反应条件
sodium methylate in methanol; nitrogen; water; ethyl acetate
参考文献
Hoechst Celanese Corporation
Patent: US5107034 A1, 1992 ;
