(R)-(-)-3-羟基丁酸乙酯合成路线 （共 32 条）
反应条件
(S)-4,12-bis(diphenylphosphino)-lt;2.2gt;paracyclophane-Ru(II)bis(trifluoroacetate); hydrogen; tetra-(n-butyl)ammonium iodide in methanol; water T=-5°C; P=2585.7 Torr; 18 h;
参考文献
Benincori; Piccolo; Rizzo; Sannicolo
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8340 - 8347
反应条件
citrate-phosphate-borate buffer 24 h; Ambient temperaturebaker's yeast immobilized in calcium alginate; Title compound not separated from byproducts;
参考文献
Bhalerao; Chandraprakash; Babu; Fadnavis
Synthetic Communications, 1993 , vol. 23, # 9 p. 1201 - 1208
反应条件
NaBO3 in tetrahydrofuran; water T=20°C;
参考文献
Lee, Ji-Eon; Yun, Jaesook
Angewandte Chemie - International Edition, 2008 , vol. 47, # 1 p. 145 - 147
反应条件
alcohol dehydrogenase from Thermoanaerobium brockii; NADH-specific (R)-selective-ADH; YcnD-oxidoreductase T=30°C; pH=7.5; 24 h; aq. bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantiospecific reaction;
参考文献
Voss, Constance V.; Gruber, Christian C.; Faber, Kurt; Knaus, Tanja; Macheroux, Peter; Kroutil, Wolfgang
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13969 - 13972
反应条件
lt;(+)-2,2'-bis(diphenylphosphino)-4,4',6,6'-tetramethyl-3,3'-bibenzolt;bgt;thiophenegt;RuCl2; hydrogen in methanol T=70°C; P=73550.8 Torr; 2 h; Yield given;
参考文献
Benincori, Tiziana; Brenna, Elisabetta; Sannicolo, Franco; Trimarco, Licia; Antognazza, Patrizia; et al.
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6244 - 6251
反应条件
sulfuric acid in 1,2-dichloro-ethane Heating;
参考文献
Jamieson, Andrew G.; Sutherland, Andrew; Willis, Christine L.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 6 p. 808 - 809
反应条件
sulfuric acid in 1,2-dichloro-ethane 48 h; Heating;
参考文献
Tetrahedron Letters, , vol. 25, # 26 p. 2747 - 2750
反应条件
sulfuric acid in 1,2-dichloro-ethane 96 h; Heating;
参考文献
O'Neill; Lindell; Simpson; Willis
Tetrahedron Asymmetry, 1994 , vol. 5, # 1 p. 117 - 118
反应条件
1: 90 percent / (n-Bu4)N(1+)*NO3(1-) / benzene / 6 h / Heating 2: H2 / Pd/C / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 26, # 28 p. 3369 - 3372
反应条件
hydrogen; palladium on activated charcoal in methanol Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 26, # 28 p. 3369 - 3372
