(R)-(-)-3-羟基丁酸乙酯合成路线 （共 32 条）
反应条件
Candida antarctica lipase B T=40 - 45°C; P=8 - 10 Torr; 72 h; Microbiological reaction;
参考文献
Isis Innovation Limited; Government of the USA, as Represented by the Secretary , Department of Health And; Human Services
Patent: US2011/237666 A1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 1) diisopropyl amine, n-BuLi / 1) THF, -45 deg C to -20 deg C in 1.5 h; 2) -78 deg C to -20 deg C in 20 h
2: 46.1 g / trifluoroacetic acid / 18 h / Ambient temperature
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参考文献
Sutter; Seebach
1983 , vol. No. 6, p. 939 - 949
