N-(1-羟基-2-(羟基甲基)-4-(4-辛基苯基)-2-丁基)乙酰胺合成路线 （共 16 条）
反应条件
sodium tetrahydroborate; water; calcium chloride in ethanol T=0°C;
参考文献
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; HAUFE, Guenter; LEVKAU, Bodo; SCHAEFERS, Michael; SCHILSON, Stefani Silke; KEUL, Petra
Patent: WO2013/26765 A1, 2013 ;
Location in patent: Page/Page column 65-66 ;
反应条件
sodium hydrogencarbonate in chloroform
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Tomatsu, Ayumi; Chino, Masao; Takeda, Shuzo; Tanaka, Yoshihito; Maeda, Yasuhiro; Sato, Noriko; Mitsutomi, Naoko; Sugahara, Kunio; Chiba, Kenji
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 425 - 432
反应条件
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C 7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C 7.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: 61 percent / ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 2.1: Et3N / CH2Cl2 / 1 h / 20 °C 3.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 4.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 4.2: 61 percent / ethanol / 3 h / 65 °C 5.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 2.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 2.2: 61 percent / ethanol / 3 h / 65 °C 3.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C 6.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
