tetrabutylammomium bromide; potassium carbonate; palladium diacetate in water T=20°C; 2 h;

potassium acetate; palladium diacetate in N,N-dimethyl acetamide T=150°C; Heck reaction; 20 h; Inert atmosphere;

1: (4-fluoro-phenyl)-magnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere; chemoselective reaction;

tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether T=80°C; Suzuki cross-coupling; 41 h;