2-[4-(苄氧基)苯基]-N-甲基乙胺盐酸盐(1:1)合成路线 （共 5 条）
反应条件
1: With sodium tetrahydroborate; acetic acid in 1,4-dioxane T=15 - 70°C; 5.25 - 5.33333 h; 2: With hydrogenchloride in dichloromethane 12 - 14 h; Product distribution / selectivity;
参考文献
Bolugoddu, Vijaya Bhaskar; Shukla, Sanjay; Jambula, Mukunda Reddy; Sagyam, Rajeshwar Reddy; Pingili, Ramchandra Reddy; Thirunavakarasu, Ananda Babu
Patent: US2006/9640 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
1.1: NaH / dimethylformamide / 0 °C 1.2: 84 percent / dimethylformamide / 2.75 h / 0 - 20 °C 2.1: 89 percent / HCl / ethyl acetate / 20 °C View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1.1: 91 percent / aq. NaHCO3 / tetrahydrofuran / 24 h 2.1: 58 percent / K2CO3 / dimethylformamide / 20 °C 3.1: NaH / dimethylformamide / 0 °C 3.2: 84 percent / dimethylformamide / 2.75 h / 0 - 20 °C 4.1: 89 percent / HCl / ethyl acetate / 20 °C View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
1.1: 58 percent / K2CO3 / dimethylformamide / 20 °C 2.1: NaH / dimethylformamide / 0 °C 2.2: 84 percent / dimethylformamide / 2.75 h / 0 - 20 °C 3.1: 89 percent / HCl / ethyl acetate / 20 °C View Scheme
参考文献
Hart, Matthew E.; Suchland, Katherine L.; Miyakawa, Motonori; Bunzow, James R.; Grandy, David K.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 1101 - 1112
反应条件
sodium hydroxide in chloroform; water 0.416667 - 0.5 h;
参考文献
Bolugoddu, Vijaya Bhaskar; Shukla, Sanjay; Jambula, Mukunda Reddy; Sagyam, Rajeshwar Reddy; Pingili, Ramchandra Reddy; Thirunavakarasu, Ananda Babu
Patent: US2006/9640 A1, 2006 ;
Location in patent: Page/Page column 7 ;
