3-溴-4-碘苯甲酸甲基酯合成路线 （共 5 条）
反应条件
iodine; potassium iodide; sodium nitrite Inert atmosphere;
参考文献
Garcia-Fortanet, Jorge; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 42 p. 8108 - 8111
反应条件
N-bromosuccinmide; sulfuric acid T=20°C; Bromination; 15 h;
参考文献
Vu, Chi B.; Corpuz, Evelyn G.; Merry, Taylor J.; Pradeepan, Selvaluxmi G.; Bartlett, Catherine; Bohacek, Regine S.; Botfield, Martyn C.; Eyermann, Charles J.; Lynch, Berkley A.; MacNeil, Ian A.; Ram, Mary K.; Van Schravendijk, Marie Rose; Violette, Shelia; Sawyer, Tomi K.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4088 - 4098
反应条件
1.1: sulfuric acid / 20 h / Reflux 2.1: hydrogenchloride; sodium nitrite / water / 1.25 h / 0 °C 2.2: 24 h / 0 - 20 °C / Darkness View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 25 p. 4907 - 4915
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran T=20°C; 12 h; Inert atmosphere;
参考文献
Naoe, Saori; Suzuki, Yamato; Hirano, Kimio; Inaba, Yusuke; Oishi, Shinya; Fujii, Nobutaka; Ohno, Hiroaki
Journal of Organic Chemistry, 2012 , vol. 77, # 11 p. 4907 - 4916
反应条件
sodium hydroxide in tetrahydrofuran
T=20°C; Hydrolysis; 3 h;
参考文献
Vu, Chi B.; Corpuz, Evelyn G.; Merry, Taylor J.; Pradeepan, Selvaluxmi G.; Bartlett, Catherine; Bohacek, Regine S.; Botfield, Martyn C.; Eyermann, Charles J.; Lynch, Berkley A.; MacNeil, Ian A.; Ram, Mary K.; Van Schravendijk, Marie Rose; Violette, Shelia; Sawyer, Tomi K.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4088 - 4098
