3-甲氧基-4-甲基苯甲醛合成路线 （共 24 条）
反应条件
Dess-Martin periodane in dichloromethane T=0°C; 0.5 h;
参考文献
ZAPAQ, INC.; THE BOARD OF TRUSTEES OF THE UNVERSITY OF ILLINOIS; OKLAHOMA MEDICAL RESEARCH FOUNDATION
Patent: WO2006/110668 A1, 2006 ;
Location in patent: Page/Page column 65 ;
WO 2006/110668 A1
反应条件
palladium in tetrahydrofuran
反应条件
1: 3-methoxy-benzaldehyde With 1-methyl-piperazine; n-butyllithium in tetrahydrofuran; hexane T=-20°C; 0.5 h; 2: With sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane 0.166667 h; 3: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-78 - 20°C; Further stages.;
参考文献
Austin, Mark; Egan, Oliver J.; Tully, Raymond; Pratt, Albert C.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 23 p. 3778 - 3786
反应条件
potassium hydroxide T=45°C;
参考文献
Flitsch; Russkamp; Langer
1985 , vol. 1985, # 7 p. 1413 - 1421
反应条件
(i) SOCl2, (ii) Li<AlH(OtBu)3>; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 13, p. 26 - 30
参考文献
Kretzschmann, H.; Meier, H.
Journal fuer Praktische Chemie/Chemiker-Zeitung, 1994 , vol. 336, # 3 p. 255 - 259
反应条件
1: 88 percent / LiAlH4 / diethyl ether / 2.5 h / Heating 2: 90 percent / active MnO2 / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 7 p. 1852 - 1856
反应条件
1: K2CO3 / acetone / 10 h / Heating 2: LiAlH4 / tetrahydrofuran / 20 °C 3: MnO2 / CHCl3 / 3 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 22 p. 3758 - 3764
反应条件
1: 91 percent / KNO3 / H2SO4 3: 91 percent / 33 percent KOH / 45 °C View Scheme
参考文献
, vol. 1985, # 7 p. 1413 - 1421
反应条件
hydrogenchloride; N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium 1) ether, cyclohexane, -72 deg C, 1 h; 2) ether, cyclohexane, -72 deg C --> rt; 3) THF, reflux, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 61, # 14 p. 4812 - 4815
