2-溴-1,3-双(溴乙基)苯合成路线 （共 13 条）
反应条件
N-bromosuccinmide in acetonitrile T=20°C; Inert atmosphere;
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 36 ;
WO 2012/139775 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile; bromine in benzene 24 h; Reflux;
参考文献
Motto, John M.; Castillo, Alvaro; Greer, Alexander; Montemayer, Laura K.; Sheepwash, Erin E.; Schwan, Adrian L.
Tetrahedron, 2011 , vol. 67, # 5 p. 1002 - 1010
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene 24 h; Heatingirradiation;
参考文献
Harvey, Ronald G.; Dai, Qing; Ran, Chongzhao; Penning, Trevor M.
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2024 - 2032
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene 24 h; Heatingirradiation;
参考文献
Harvey, Ronald G.; Dai, Qing; Ran, Chongzhao; Penning, Trevor M.
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2024 - 2032
反应条件
1: 41 percent / NaH / tetrahydrofuran / 48 h / Heating 2: 1.) n-butyllithium, 2.) SO2 / 1.) THF, hexane, -78 deg C, 2 h, 2.) -78 deg C, 30 min View Scheme
参考文献
Skowronska-Ptasinska, Maria; Telleman, Pieter; Aarts, Veronika M. L. J.; Grootenhuis, Peter D. J.; Eerden, Johan van; et. al.
Tetrahedron Letters, 1987 , vol. 28, # 17 p. 1937 - 1940
反应条件
formic acid Heating;
参考文献
Diel, Bruce N.; Han, Mingcheng; Kole, Panna L.; Boaz, David B.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 551 - 553
反应条件
1: 60 percent / NaH / tetrahydrofuran / 48 h / Heating 2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 2 h, 2.) -78 deg C, 30 min View Scheme
参考文献
Skowronska-Ptasinska, Maria; Telleman, Pieter; Aarts, Veronika M. L. J.; Grootenhuis, Peter D. J.; Eerden, Johan van; et. al.
Tetrahedron Letters, 1987 , vol. 28, # 17 p. 1937 - 1940
反应条件
1.1: potassium carbonate; potassium iodide / pentan-3-one / 48 h / Reflux 2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2.5 h / -78 °C 2.2: 3 h / 20 °C 2.3: pH Ca. 10 View Scheme
参考文献
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
Patent: US2011/319620 A1, 2011 ;
反应条件
1: 70 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / Heating
View Scheme
参考文献
Harvey, Ronald G.; Lim, Keunpoong; Dai, Qing
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1372 - 1373
反应条件
in acetonitrile
Heating;
参考文献
Poleschner, Helmut; Seppelt, Konrad
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6565 - 6574
