(R)-1-N-BOC-哌啶-2-乙醇合成路线 （共 25 条）
反应条件
sodium carbonate in methanol T=20°C; 4 h;
参考文献
Angoli, Marco; Barilli, Alessio; Lesma, Giordano; Passarella, Daniele; Riva, Sergio; Silvani, Alessandra; Danieli, Bruno
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9525 - 9527
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
Chausset-Boissarie, Laetitia; Arvai, Roman; Cumming, Graham R.; Guenee, Laure; Kuendig, E. Peter
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6473 - 6479
反应条件
1: With benzoic acid in chloroform T=-50 - -30°C; aza-Michael addition; 44 h; 2: With sodium tetrahydroborate in methanol; chloroform T=0°C; 0.5 h; Further stages. Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 9, # 25 p. 5283 - 5286
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; Reduction; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2621 - 2624
反应条件
1.1: 69 percent / AcCl / toluene / Heating 2.1: Vitride / toluene / -78 °C 2.2: 60 percent / HCl 3.1: TiCl4 / toluene / 50 °C 4.1: K2CO3 / acetone 5.1: OsO4; NaIO4 / dioxane; H2O 6.1: LiAlH4 / diethyl ether / Heating 6.2: 52 percent / H2 / Pd-C / methanol 7.1: NaOH / dioxane; H2O View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: TiCl4 / toluene / 50 °C 2.1: K2CO3 / acetone 3.1: OsO4; NaIO4 / dioxane; H2O 4.1: LiAlH4 / diethyl ether / Heating 4.2: 52 percent / H2 / Pd-C / methanol 5.1: NaOH / dioxane; H2O View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: Vitride / toluene / -78 °C 1.2: 60 percent / HCl 2.1: TiCl4 / toluene / 50 °C 3.1: K2CO3 / acetone 4.1: OsO4; NaIO4 / dioxane; H2O 5.1: LiAlH4 / diethyl ether / Heating 5.2: 52 percent / H2 / Pd-C / methanol 6.1: NaOH / dioxane; H2O View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: LiAlH4 / diethyl ether / Heating 1.2: 52 percent / H2 / Pd-C / methanol 2.1: NaOH / dioxane; H2O View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: K2CO3 / acetone 2.1: OsO4; NaIO4 / dioxane; H2O 3.1: LiAlH4 / diethyl ether / Heating 3.2: 52 percent / H2 / Pd-C / methanol 4.1: NaOH / dioxane; H2O View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
sodium hydroxide in 1,4-dioxane; water
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
